The Effectiveness of Metformin and Glimepiride Therapy on Reducing Blood Glucose Levels in Patients with Diabetes Mellitus

Abstract

Diabetes mellitus is a chronic condition that occurs when the pancreas can no longer produce insulin or the body cannot effectively use the insulin it produces. This study aims to determine the effectiveness of metformin and glimepiride in reducing blood glucose levels in diabetes mellitus patients. The study is observational with a cross-sectional retrospective approach, conducted at Puskesmas Balerejo Madiun in February 2024 with a total of 48 respondents. Data analysis was performed using the Mann-Whitney test. Demographic data showed that 25 respondents (52.1%) were female, 28 respondents (58.3%) were aged 36-45 years, 22 respondents (45.8%) had a high school education, 14 respondents (29.2%) were farmers/livestock traders/vendors, and 21 respondents (43.8%) had a normal BMI. The pre-treatment mean fasting blood glucose (FBG) for metformin was 171.96±82.737 and post-treatment was 143.88±58.062. For glimepiride, the pre-treatment mean FBG was 178.21±67.791 and post-treatment was 152.08±63.959